Cell Membrane Repair 2023/2024
Cellular response that seals ruptures in the plasma membrane in order to maintain homeostasis and prevent death.
A cell’s viability depends directly on the integrity of its plasma membrane and its ability to repair it after rupture events. Pathogenic microorganisms secrete powerful virulence factors, such as toxins, which bind to target cells, forming pores in the plasma membrane. In response, proteins from the cytoskeleton (e.g. actin) and the extracellular matrix (e.g. cadherin) work in concert to resist these injuries, thus representing a mechanism of resistance to cell death.
Originals *
CADHERINS from H292 cells
Response of H292 cell caderins to a pore-forming bacterial toxin. Caderins are transmembrane proteins responsible for cell-cell adhesion.
ACTIN from HeLa cells
Actin response to a bacterial toxin that forms pores. The protein actin is one of the fundamental elements of the cellular skeleton.
ACTIN from HeLa cells
Actin response to a bacterial toxin that forms pores. The protein actin is one of the fundamental elements of the cellular skeleton.
*Source: Institute for Research and Innovation in Health (i3S) – Cell Biology of Bacterial Infections
